Small Cell Carcinoma of the Lung.
Small cell carcinoma has a very distinctive set of cytological features. Like other cancerous cells they tend to be larger than normal. Their “small cell” naming comes from the fact that cell size is still relatively small compared to typical cancerous cells. They have characteristically large nuclei and a thin rim of cytoplasm along the outside. The cells typically have a salt and pepper chromatin appearance or granular chromatin. Small cell carcinomas also have a tendency to mold their nuclei into each other, a distinctive feature.
The cells also have a very lymphoid appearance. Indeed because of this fact, and the fact that small cell carcinomas are quite aggressive presentation, they used to be mistaken for lymphomas.