Posts tagged cancer

I Do Not Fear Death by Roger Ebert

“I will pass away sooner than most people who read this, but that doesn’t shake my sense of wonder and joy.”

The essay is from Roger Ebert’s Life Itself: A Memoir and was published to Salon as a memorial of sorts for a recently deceased critic and friend. It is a beautifully written essay about that final threshold to which we all find at the end of our days.

A Girl Dying from Leukaemia Saved Using Altered T-Cells

Now this is very impressive.

Last summer, Emma, then six was near death from chemo-resistant leukaemia but is now in remission thanks to an experimental cancer treatment method developed by the University of Pennsylvania.

Doctors remove millions of Emma’s T-cells, and inserted new genes that enabled them to combat cancer cells. The kicker is that it involved using disabled HIV virions to deliver the genetic material. HIV particles are excellent genetic vectors and already have specificity towards T-cells. The new genes program the T-cells to attack B-cells.

The treatment very nearly killed her but she has emerged cancer free and still in complete remission.

This is very exciting stuff but make no mistake this is no end-all-be-all. Emma might have done extremely well with her treatment but the experiment has had its share of mixed results. Despite this, the researchers involved and the experts of the field think this approach has tremendous promise.

Life, Interrupted: Five Days of Chemo

“Every month, I go to the hospital to receive outpatient chemotherapy injections for five days in a row. My doctors say this will be my routine for the next year.”

I remember when my father underwent chemotherapy. “Experimental combination,” the oncologist would say. The cancer was aggressive and advanced. A standard treatment protocol was out of consideration. There was not much they could do about his mets, but they were hopeful that chemo would prolong his life beyond the months they could foresee. 

Sadly, that never came to pass, but what did pass was the terrible after effects of chemotherapy. My father was a strong man, and even in his last days following chemo, the misery of it was plainly obvious. It is such a strange and horrible dilemma to suffer at the hands of either cancer unchecked or of the potent and toxic chemo.

To not have undergone chemo would have most likely made his last days easier, but then again, at that point, we were willing to take any chance.

Follow the link to read the first person account of Suleika Jaouad as she writes about her experiences as a young adult with cancer in the series: Life, Interrupted.

Jake Bouma meets with his oncologist on June 22, 2012, after four rounds of chemotherapy to treat his Hodgkin Lymphoma.

This clip is part of a documentary Nathan Matta is creating on his journey, “Let’s Do This: Facing Hodgkin Lymphoma.”

When I feel lost on my journey, when the challenges seem insurmountable, moments like these remind me again why I am here and why I have chosen medicine. More than that, it pushes me to continue onward.

A Process of Death

Three years ago today, I personally had an experience with the final days of a man. I can still remember watching this once proud and grown man grow weak and frail as his cancer progressed. I remember this man being healthy only months before lying in a bed, eyes closed and lips pursed, wrestling internally with the rebellious cells of his body and the toxic therapy coursing through his veins. I remember refusing to give into the truth that lay before me.

That this man was my father.

Cancer-killing nano particle system created by 17-year-old

All it takes is a fresh new perspective, commitment and innovative thinking to take something to the next level. 17-year-old Angela Zhang, under the mentorship of Dr. Zhen Cheng of Stanford University, has created a potential “Swiss army knife” of cancer therapy. Not only has her research yielded nano particles that target cancer stem cells, it also has the capacity to allow current imaging techniques to track the therapy in real time. 

Did I mention she is 17? Absolutely amazing work.

My tumor is situated in the pelvic girdle inside the bone and growing out into the pelvis, and I find it difficult to imagine what it really looks like. I feel that it is an uninvited guest in my body and when I started this cytotoxic treatment I thought: Now this is for you.
Cancer patient describing her experience with treatment.
Osteosarcoma.
While not exactly the main topic of this week’s material, this radiograph reminds me of a prior saying from a doctor that is more and more relevant every day: “Focus on knowing the normal. Be able to see things and identify them as normal. When you do, the abnormal will just jump out at you.” After having been exposed to some radiographs, I am slowly developing a feel for what “normal” is. Even if I do not know how to name this, I can at least say that it looks abnormal; that is a start.

Osteosarcoma.

While not exactly the main topic of this week’s material, this radiograph reminds me of a prior saying from a doctor that is more and more relevant every day: “Focus on knowing the normal. Be able to see things and identify them as normal. When you do, the abnormal will just jump out at you.” After having been exposed to some radiographs, I am slowly developing a feel for what “normal” is. Even if I do not know how to name this, I can at least say that it looks abnormal; that is a start.

Auer rods in acute myeloid leukaemia.
In histology, acute myeloid leukaemia can be distinguished from acute lymphocytic leukaemia by cell morphology and the presence of Auer rods. These are aggregations of myeloid granules that form elongated needle-like structures in the cytoplasm of leukaemia blasts. 

Auer rods in acute myeloid leukaemia.

In histology, acute myeloid leukaemia can be distinguished from acute lymphocytic leukaemia by cell morphology and the presence of Auer rods. These are aggregations of myeloid granules that form elongated needle-like structures in the cytoplasm of leukaemia blasts. 

Reed-Sternberg Cell.
Historically, lymphoma has been categorized into two types: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Hodgkin’s lymphoma was first described by Thomas Hodgkin in 1832. It is a cancer of the lymph tissue found in lymph nodes, spleen, liver, bone marrow and other sites. The diagnosis can be made by identifying the Reed-Sternberg cell in the involved lymphoid tissue. Classically, this cell is large and binucleate, with each nucleus containing a prominent nucleolus, giving it the appearance of “owl eyes.”

Reed-Sternberg Cell.

Historically, lymphoma has been categorized into two types: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Hodgkin’s lymphoma was first described by Thomas Hodgkin in 1832. It is a cancer of the lymph tissue found in lymph nodes, spleen, liver, bone marrow and other sites. The diagnosis can be made by identifying the Reed-Sternberg cell in the involved lymphoid tissue. Classically, this cell is large and binucleate, with each nucleus containing a prominent nucleolus, giving it the appearance of “owl eyes.